NeuroLight

Pupillometer

Clinical studies

NeuroLight Pupillometer

Clinical Studies

Click on each title for the link of the studies

Clinical References in Neurological Assessment

  1. The effect of ambient-light conditions on quantitative pupillometry: a history of rubber cup. D. Couret, P. Simeone, S. Freppel and L. Velly
  2. Editor letter for Sanna Holmskär “Is quantitative pupillometry affected by ambient light? A prospective crossover study. J Clin Monit Comput, 2025” | Journal of Clinical Monitoring and Computing
  3. Application of Pupillometry in Neurocritical Patients. Hsu CH, Kuo LT. J Pers Med. 2023;13(7):1100. doi:10.3390/jpm13071100
  4. Zorzi S. et al. Poster: Normal values of the new QPi index from automated pupillometry. 2023.
  5. Blandino Ortiz A. et al. Poster: Assessment equivalence between NPi and QPi in acute brain injury. 2023.
  6. Reliability of standard pupillometry practice in neurocritical care: an observational, double-blinded study | Critical Care | Full Text
  7. Neurological Complications and Noninvasive Multimodal Neuromonitoring in Critically Ill Mechanically Ventilated COVID-19 Patients Denise Battaglini, Gregorio Santori, Chiara Robba et al. doi: 10.3389/fneur.2020.602114.

Traumatic and non-traumatic brain injury

 

8. Blandino Ortiz A. et al. Poster: Assessment equivalence between NPi and QPi in acute brain injury. 2023.

9. Zorzi S. et al. Poster: Normal values of the new QPi index from automated pupillometry. 2023.

10. Prognostic role of quantitative pupillometry in traumatic brain injury: a scoping review – PubMed

11. Comparison between Neurologial Pupil Index and Quantitative Pupillometry Index to prognosticate outcome after cardiac arrest, Taccone et al.

12. Early Quantitative Pupillometry index (QPi) as a predictor of long term outcome in severe traumatic brain injury patients: a prospective observational study. Basavakiran Namdar (Dehli India)

13. Editor letter for Sanna Holmskär “Is quantitative pupillometry affected by ambient light? A prospective crossover study. J Clin Monit Comput, 2025” | Journal of Clinical Monitoring and Computing

14.https://www.sciencedirect.com/science/article/abs/pii/S1474442223002715#:~:text=The%20ORANGE%20study%20was%20a,%E2%89%A44)%20at%206%20months.

15. The Neurological Pupil index for outcome prognostication in people with acute brain injury (ORANGE): a prospective, observational, multicentre cohort study – PubMed Prof Mauro Oddo et Al. Volume 22, Issue 10, October 2023, Pages 925-933 The Neurological Pupil index for outcome prognostication in people with acute brain injury (ORANGE): a prospective, observational, multicentre cohort study – ScienceDirect

Pupillometry: a non-invasive approach to ICP monitoring

 

16. Pupillometry: A loupe to mirror intracranial status during recovery after neurosurgery Brain Circulation

17. Giede-Jeppe et al. Neurocrit Care 2021;35:210-220. doi:10.1007/s12028-020-01149-1 (NPI) Quantitative Infrared Pupillometry in Nonconvulsive Status Epilepticus | Neurocritical Care

18. Noninvasive Intracranial Pressure Monitoring for Severe Traumatic Brain Injury in Children: A Concise Update on Current Methods – PubMed (QP – pas de npi ni neurolight) Noninvasive Intracranial Pressure Monitoring for Severe Traumatic Brain Injury in Children: A Concise Update on Current Methods. 2018. Narayan V, et al.​

19. Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury | Critical Care | Full Text

20. Application of Pupillometry in Neurocritical Patients – PMC

21. Diagnostic accuracy test of quantitative pupillary light reflex as an indicator of increased intracranial pressure in traumatic brain injury patients: a cross-sectional study – Universitas Airlangga (Etude PLR)

After cardiac arrest

  1. Automated quantitative pupillometry for the prognostication of coma after cardiac arrest (PubMed).
  2. Validating quantitative pupillometry thresholds for neuroprognostication after OHCA (PubMed).
  3. European Resuscitation Council Guidelines 2021 – Post-resuscitation care (Resuscitation Journal).
  4. Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest. Heimburger D, Durand M, Gaide-Chevronnay L, Dessertaine G, Moury PH, Bouzat P, Albaladejo P, Payen JF. 7 (Resuscitation).
  5. Early prediction of coma recovery after cardiac arrest with blinded pupillometry (Wiley).
  6. Comparison between Neurological Pupil Index and Quantitative Pupillometry Index for prognosis.
  7. Quantitative Pupillometry Index (QPi) in comatose patients after Cardiac Arrest (Poster).
  8. Comparison between Neurologial Pupil Index and Quantitative Pupillometry Index to prognosticate outcome after cardiac arrest, Taccone et al.

 

Detection of delirium in resuscitation by quantitative pupillometry

 

  1. Neuromonitoring of delirium with quantitative pupillometry in sedated mechanically ventilated critically ill patients Eva Favre, Adriano Bernini, Paola Morelli, Jerôme Pasquier, John-Paul Miroz, Samia Abed-Maillard, Nawfel Ben-Hamouda & Mauro Oddo (2020) https://doi.org/10.1186/s13054-020-2796-8
  2. Neurological Complications and Noninvasive Multimodal Neuromonitoring in Critically Ill Mechanically Ventilated COVID-19 Patients Denise Battaglini, Gregorio Santori, Karthikka Chandraptham, Francesca Iannuzzi, Matilde Bastianello, Fabio Tarantino, Lorenzo Ball, Daniele Roberto Giacobbe, Antonio Vena, Matteo Bassetti, Matilde Inglese, Antonio Uccelli, Patricia Rieken Macedo Rocco, Nicolò Patroniti, Iole Brunetti, Paolo Pelosi, Chiara Robba (2020) https://pubmed.ncbi.nlm.nih.gov/33329361/
  3. Association Between Pupil Light Reflex and Delirium in Adults With Traumatic Brain Injury: Preliminary Findings Alexandra Lapierre, Annie Proulx, Céline Gélinas, Stéphanie Dollé, Sheila Alexander, David Williamson, Francis Bernard, Caroline Arbour (2024) https://pubmed.ncbi.nlm.nih.gov/38833515/
  4. La pupillométrie pour anticiper le délirium à l’unité des soins intensifs Caroline Arbour, Réseau de recherche en interventions en sciences infirmières du Québec (RRISIQ), October 2024

 

Diagnosis of brain death

  1. Validating quantitative pupillometry thresholds for neuroprognostication after out-of-hospital cardiac arrest. A predefined substudy of the Blood Pressure and Oxygenations Targets After Cardiac Arrest (BOX)-trial – PubMed
  2. Atypical Pupil Reactions in Brain Dead Patients
  3. Pupillométrie automatisée pour l’évaluation neurologique post-arrêt cardiaque : le regard qui tue ? | SRLF
  4. Donation after brainstem death – ODT Clinical – NHS Blood and Transplant
  5. UK Code of Practice for the Diagnosis and Confirmation of Death
  6. https://www.organdonation.nhs.uk/
  7. European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care | Intensive Care Medicine
  8. https://pubmed.ncbi.nlm.nih.gov/39162825/
  9. https://pmc.ncbi.nlm.nih.gov/articles/PMC11021299/

 

QPi score:

  1. Application of Pupillometry in Neurocritical Patients – PMC Journal of Personalized Medicine July 2023, Chiu-Hao Hsu et al. doi.org/10.3390/jpm13071100
  2. QUANTITATIVE PUPILLOMETRY INDEX (QPI) IN COMATOSE PATIENTS AFTER CARDIAC ARREST
  3. Pupillary Light Reflex (Chapter 8) – A Practical Guide to Portable Pupillometry
  4. Comparison between NeuroLogical Pupil Index and Quantitative Pupillometry Index to prognosticate outcome after cardiac arrest, Poster EuroNeuro 2024, M. Pasetto et Al.
  5. EQUIVALENCE ASSESSMENT BETWEEN NPi and QPi pupilometry rates vs subjective pupilometry in patients with acute brain injury, Poster SEEIUC 2024, C. Serrano Gonzalez et Al.
  6. Assessment equivalence between pupillometry indices NPi and QPi in acute brain injury patients, Poster ESICM 2023, Blandino Ortiz et Al.
  7. Comparison between NeuroLogical Pupil Index and Quantitative Pupillometry Index to prognosticate outcome after cardiac arrest, Poster EuroNeuro 2024, M. Pasetto et Al.

      *The technology | NPi-200 for pupillary light reflex in critical care patients | Advice | NICE