Pupillomètre NeuroLight

Etudes cliniques

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Clinical References in Neurological Assessment

1. Couret D, Simeone P, Freppel S, Velly L. The effect of ambient-light conditions on quantitative pupillometry: a history of rubber cup. Neurocrit Care. 2019 Apr;30(2):492-493. doi: 10.1007/s12028-018-0664-z. PMID: 30604030.

2. Couret D, Doucet W, Asmolov R, Simeone P, Velly L. Editor letter for Sanna Holmskär “Is quantitative pupillometry affected by ambient light? A prospective crossover study.” J Clin Monit Comput. 2025 May; doi:10.1007/s10877-025-01302-1

3. Hsu CH, Kuo LT. Application of Pupillometry in Neurocritical Patients. J Pers Med. 2023 Jul 5;13(7):1100. doi: 10.3390/jpm13071100. PMID: 37511713; PMCID: PMC10381796.

4. Zorzi S, Minemura Ordinola AA, Vathi S, Taccone FS. Normal values of the new QPI index from automated pupillometry. J Anesth Analg Crit Care. 2023;3(Suppl 1):A125. Abstracts of the ICARE 2023 – 77th SIAARTI National Congress.

5. Blandino Ortiz A, López Olvencia M, Higuera J, Soriano Cuesta C, Saez Noguero S, Montufar Ramírez JA, Vaquero C, De Pablo R. Assessment equivalence between pupillometry indices NPi and QPi in acute brain injury patients. ESICM Congress Abstracts; 2023. Poster presentation.

6. Couret D, Boumaza D, Grisotto C, Triglia T, Pellegrini L, Ocquidant P, Bruder NJ, Velly LJ. Reliability of standard pupillometry practice in neurocritical care: an observational, double-blinded study. Crit Care. 2016 Mar 13;20:99. doi: 10.1186/s13054-016-1239-z. PMID: 27072310; PMCID: PMC4828754.

7. Battaglini D, Santori G, Chandraptham K, Iannuzzi F, Bastianello M, Tarantino F, Ball L, Giacobbe DR, Vena A, Bassetti M, Inglese M, Uccelli A, Rocco PRM, Patroniti N, Brunetti I, Pelosi P, Robba C. Neurological Complications and Noninvasive Multimodal Neuromonitoring in Critically Ill Mechanically Ventilated COVID-19 Patients. Front Neurol. 2020 Nov 27;11:602114. doi: 10.3389/fneur.2020.602114. PMID: 33329361; PMCID: PMC7729072.

8. Rodríguez González D, Sanjuán Navías M, Fuentes Mila V, Arboledas Triviño C, Barranco Rodríguez A, Giménez Villa V, Nogales Ibáñez RM, Corral Ansa L, Via Clavero G. Agreement and correlation between manual and quantitative pupillometry in neurocritical patients. Poster presented at: 50th Congreso Nacional de la Sociedad Española de Enfermería Intensiva y Unidades Coronarias (SEEIUC); 2025 Jun 15–18; Valencia, Spain.

14. Giménez Villa, V., Arboledas Triviño, C., Fuentes Mila, V., Sanjuán Navias, M., Rodríguez González, D., Barranco Rodríguez, A., Mogoles Ibáñez, R. M., & Via Clavero, G. (2025, June 15–18). Monitoring of pupils using automated quantitative pupillometry in an intensive care unit. Poster presented at the 50th Congreso Nacional de la SEEIUC, Valencia, Spain.

39. Fuentes Mila, V., Barranco Rodríguez, A., Sanjuán Navías, M., Giménez Villa, V., Rodríguez González, D., Arboledas Triviño, C., Nogales Ibáñez, R. M., Corral Ansa, L., & Via Clavero, G. (2025, June 15–18). Comparative analysis of pupil monitoring using manual versus automated pupillometry in a cohort of neurocritical patients. Poster presented at the 50th Congreso Nacional de la SEEIUC, Valencia, Spain.

Traumatic and non-traumatic brain injury

9. Zorzi S, Minemura Ordinola AA, Vathi S, Taccone FS. Normal values of the new QPI index from automated pupillometry. J Anesth Analg Crit Care. 2023;3(Suppl 1):A125. Abstracts of the ICARE 2023 – 77th SIAARTI National Congress.

12. Goyal K, Namdar B, Rath GP, Pandia MP. Poster: Early Quantitative Pupillometry index (QPi) as a predictor of long term outcome in severe traumatic brain injury patients: a prospective observational study. Presented at Neurocritical Care Society (NCS) Annual Meeting 2025, session 139 (poster ABS124).

13. Couret D, Doucet W, Asmolov R, Simeone P, Velly L. Editor letter for Sanna Holmskär “Is quantitative pupillometry affected by ambient light? A prospective crossover study.” J Clin Monit Comput. 2025 May; doi:10.1007/s10877-025-01302-1

15. Oddo M, Taccone FS, Petrosino M, Badenes R, Blandino-Ortiz A, Bouzat P, Caricato A, Chesnut RM, Feyling AC, Ben-Hamouda N, Hemphill JC, Koehn J, Rasulo F, Suarez JI, Elli F, Vargiolu A, Rebora P, Galimberti S, Citerio G; ORANGE study investigators.The Neurological Pupil index for outcome prognostication in people with acute brain injury (ORANGE): a prospective, observational, multicentre cohort study. Lancet Neurol. 2023 Oct;22(10):925-933. doi: 10.1016/S1474-4422(23)00271-5. Epub 2023 Aug 28. PMID: 37652068.

Pupillometry: a non-invasive approach to ICP monitoring

16. Palaniswamy SR, Mishra R, Sikaria A, Murthy S. Pupillometry: A loupe to mirror intracranial status during recovery after neurosurgery. Brain Circ. 2025 Jun 9;11(3):247-249. doi: 10.4103/bc.bc_19_25. PMID: 40842445; PMCID: PMC12367254.

17. Godau J, Bierwirth C, Rösche J, Bösel J. Quantitative Infrared Pupillometry in Nonconvulsive Status Epilepticus. Neurocrit Care. 2021 Aug;35(1):113-120. doi: 10.1007/s12028-020-01149-1. Epub 2020 Nov 20. PMID: 33215395. (NPI)

18. Narayan V, Mohammed N, Savardekar AR, Patra DP, Notarianni C, Nanda A. Noninvasive Intracranial Pressure Monitoring for Severe Traumatic Brain Injury in Children: A Concise Update on Current Methods. World Neurosurg. 2018 Jun;114:293-300. doi: 10.1016/j.wneu.2018.02.159. Epub 2018 Mar 8. PMID: 29524721. (qPLR)

19. Jahns FP, Miroz JP, Messerer M, Daniel RT, Taccone FS, Eckert P, Oddo M. Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury. Crit Care. 2019 May 2;23(1):155. doi: 10.1186/s13054-019-2436-3. PMID: 31046817; PMCID: PMC6498599.

20. Hsu CH, Kuo LT. Application of Pupillometry in Neurocritical Patients. J Pers Med. 2023 Jul 5;13(7):1100. doi: 10.3390/jpm13071100. PMID: 37511713; PMCID: PMC10381796. (qPLR)

21. Dhania A. Santosa, Edward Kusuma, Nancy Margarita Rehatta. Diagnostic accuracy test of quantitative pupillary light reflex as an indicator of increased intracranial pressure in traumatic brain injury patients: a cross-sectional study Faculty of Medicine Department of Anesthesiology and Reanimation Medical. Published: 2023-08-19. doi:10.15562/bmj.v12i3.4523 (qPLR)

After cardiac arrest

22. Suys T, Bouzat P, Marques-Vidal P, Sala N, Payen JF, Rossetti AO, Oddo M. Automated quantitative pupillometry for the prognostication of coma after cardiac arrest. Neurocrit Care. 2014 Oct;21(2):300-8. doi: 10.1007/s12028-014-9981-z. PMID: 24760270.

23. Nyholm B, Grand J, Obling LER, Hassager C, Møller JE, Schmidt H, Othman MH, Kondziella D, Horn J, Kjaergaard J. Validating quantitative pupillometry thresholds for neuroprognostication after out-of-hospital cardiac arrest. A predefined substudy of the Blood Pressure and Oxygenations Targets After Cardiac Arrest (BOX)-trial. Intensive Care Med. 2024 Sep;50(9):1484-1495. doi: 10.1007/s00134-024-07574-6. Epub 2024 Aug 20. PMID: 39162825; PMCID: PMC11377455.

24. Nolan JP, Sandroni C, Böttiger BW, Cariou A, Cronberg T, Friberg H, Genbrugge C, Haywood K, Lilja G, Moulaert VRM, Nikolaou N, Olasveengen TM, Skrifvars MB, Taccone F, Soar J. European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care. Intensive Care Med. 2021 Apr;47(4):369-421. doi: 10.1007/s00134-021-06368-4. Epub 2021 Mar 25. PMID: 33765189; PMCID: PMC7993077.

25. Heimburger D, Durand M, Gaide-Chevronnay L, Dessertaine G, Moury PH, Bouzat P, Albaladejo P, Payen JF. Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest. Resuscitation. 2016 Jun;103:88-93. doi:10.1016/j.resuscitation.2016.02.026. Epub 2016 Mar 9. PMID: 26970030.

26. Solari D, Rossetti AO, Carteron L, Miroz JP, Novy J, Eckert P, Oddo M. Early prediction of coma recovery after cardiac arrest with blinded pupillometry. Ann Neurol. 2017 Jun;81(6):804-810. doi: 10.1002/ana.24943. Epub 2017 Jun 2. PMID: 28470675.

27. M. Pasetto, S. Zorzi, S. Castellani, M. Zaccherelli, F.S. Taccone. Comparison between Neurological Pupil Index and Quantitative Pupillometry Index (QPi) to prognosticate outcome after cardiac arrest, Poster EuroNeuro 2024.

28. S. Zorzi, M. Pasetto, G. Furlan, M. Zaccarelli, M. Polato, A. Vieno, M. Savi, E.D. Sterchele, L. Calabrò, M. Salvagno, M. Anderloni, E. Gouvea Bogossian, A. Blandino-Ortiz, F.S. Taccone Quantitative Pupillometry Index (QPi) in comatose patients after Cardiac Arrest . Poster EuroNeuro 2024.

29. M. Pasetto, S. Zorzi, S. Castellani, M. Zaccherelli, F.S. Taccone. Comparison between Neurological Pupil Index and Quantitative Pupillometry Index (QPi) to prognosticate outcome after cardiac arrest, Poster EuroNeuro 2024.

Detection of delirium in resuscitation by quantitative pupillometry

30. Favre E, Bernini A, Morelli P, Pasquier J, Miroz JP, Abed-Maillard S, Ben-Hamouda N, Oddo M. Neuromonitoring of delirium with quantitative pupillometry in sedated mechanically ventilated critically ill patients. Crit Care. 2020 Feb 24;24(1):66. doi: 10.1186/s13054-020-2796-8. PMID: 32093710; PMCID: PMC7041194.

31. Battaglini D, Santori G, Chandraptham K, Iannuzzi F, Bastianello M, Tarantino F, Ball L, Giacobbe DR, Vena A, Bassetti M, Inglese M, Uccelli A, Rocco PRM, Patroniti N, Brunetti I, Pelosi P, Robba C. Neurological Complications and Noninvasive Multimodal Neuromonitoring in Critically Ill Mechanically Ventilated COVID-19 Patients. Front Neurol. 2020 Nov 27;11:602114. doi: 10.3389/fneur.2020.602114. PMID: 33329361; PMCID: PMC7729072.

32. Lapierre A, Proulx A, Gélinas C, Dollé S, Alexander S, Williamson D, Bernard F, Arbour C. Association Between Pupil Light Reflex and Delirium in Adults With Traumatic Brain Injury: Preliminary Findings. J Neurosci Nurs. 2024 Aug 1;56(4):107-112. doi: 10.1097/JNN.0000000000000763. Epub 2024 May 31. PMID: 38833515.

33. Caroline Arbour, La pupillométrie pour anticiper le délirium à l’unité des soins intensifs , Réseau de recherche en interventions en sciences infirmières du Québec (RRISIQ), October 2024.

50. Proulx A, Lapierre A, Bernard F, Arbour C. La pupillométrie pour prédire le délirium aux soins intensifs neurologiques. Montréal: CIUSSS du Nord-de-l’Île-de-Montréal; 2024. Poster de recherche présenté dans le cadre du RIISIQ 2024.

Diagnosis of brain death

34. Nyholm B, Grand J, Obling LER, Hassager C, Møller JE, Schmidt H, Othman MH, Kondziella D, Horn J, Kjaergaard J. Validating quantitative pupillometry thresholds for neuroprognostication after out-of-hospital cardiac arrest. A predefined substudy of the Blood Pressure and Oxygenations Targets After Cardiac Arrest (BOX)-trial. Intensive Care Med. 2024 Sep;50(9):1484-1495. doi: 10.1007/s00134-024-07574-6. Epub 2024 Aug 20. PMID: 39162825; PMCID: PMC11377455.

35. Sołek-Pastuszka J, Zegan-Barańska M, Biernawska J, Sawicki M, Iwańczuk W, Chełstowski K, Bohatyrewicz R, Dąbrowski W, Kojder K. Atypical Pupil Reactions in Brain Dead Patients. Brain Sci. 2021 Sep 10;11(9):1194. doi: 10.3390/brainsci11091194. PMID: 34573214; PMCID: PMC8466677.

36. Jonathan Chelly. Pupillométrie automatisée pour l’évaluation neurologique post-arrêt cardiaque : le regard qui tue ? Article SRLF, Mai 2019.

37. Donation after brainstem death. ODT Clinical – NHS Blood and Transplant. Best practice guidance. 2025 update.

38. Academy of Medical Royal Colleges Code of Practice for the diagnosis and confirmation of death. 2025.

40. Nolan JP, Sandroni C, Böttiger BW, Cariou A, Cronberg T, Friberg H, Genbrugge C, Haywood K, Lilja G, Moulaert VRM, Nikolaou N, Olasveengen TM, Skrifvars MB, Taccone F, Soar J. European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care. Intensive Care Med. 2021 Apr;47(4):369-421. doi: 10.1007/s00134-021-06368-4. Epub 2021 Mar 25. PMID: 33765189; PMCID: PMC7993077.

41. Nyholm B, Grand J, Obling LER, Hassager C, Møller JE, Schmidt H, Othman MH, Kondziella D, Horn J, Kjaergaard J. Validating quantitative pupillometry thresholds for neuroprognostication after out-of-hospital cardiac arrest. A predefined substudy of the Blood Pressure and Oxygenations Targets After Cardiac Arrest (BOX)-trial. Intensive Care Med. 2024 Sep;50(9):1484-1495. doi: 10.1007/s00134-024-07574-6. Epub 2024 Aug 20. PMID: 39162825; PMCID: PMC11377455.

42. Lenga P, Kühlwein D, Schönenberger S, Neumann JO, Unterberg AW, Beynon C. The use of quantitative pupillometry in brain death determination: preliminary findings. Neurol Sci. 2024 May;45(5):2165-2170. doi: 10.1007/s10072-023-07251-4. Epub 2023 Dec 12. PMID: 38082049; PMCID: PMC11021299.

QPi score

8. Blandino Ortiz A, López Olvencia M, Higuera J, Soriano Cuesta C, Saez Noguero S, Montufar Ramírez JA, Vaquero C, De Pablo R. Assessment equivalence between pupillometry indices NPi and QPi in acute brain injury patients. ESICM Congress Abstracts; 2023. Poster presentation.

12. Goyal K, Namdar B, Rath GP, Pandia MP (New Delhi, India) Poster: Early Quantitative Pupillometry index (QPi) as a predictor of long-term outcome in severe traumatic brain injury patients: a prospective observational study. Presented at Neurocritical Care Society (NCS) Annual Meeting 2025, session 139 (poster ABS124).

20. Hsu CH, Kuo LT. Application of Pupillometry in Neurocritical Patients. J Pers Med. 2023 Jul 5;13(7):1100. doi: 10.3390/jpm13071100. PMID: 37511713; PMCID: PMC10381796. (qPLR)

43. Isaac T, Khan A, Mendez I, Bouchard B. Assessing autonomic response in diabetic patients through idMed Neurolight pupillometer. University of Saskatchewan; Virtual Health Hub; Saskatchewan Health Authority. Presented at the UofS CoM Dean’s Summer Project Symposium; 2025.

45. Larson MD. Pupillary Light Reflex. In: Larson MD, editor. Pupillary Light Reflex (Chapter 8) – Practical Guide to Portable Pupillometry. Cambridge: Cambridge University Press; 2023.

47. Serrano Gonzalez C, Gonzalo Briceño M, Velasco Roncero M, Broncano Gonzalez N, Hermida Gomez S, De Pablo R, Lopez Olvencia M, Blandino Ortiz A. Equivalence evaluation between pupillometry indices NPi and QPi vs subjective pupillometry in patients with acute brain injury. Presented at: SEEIUC 2024; 2024; [poster].

*The technology | NPi-200 for pupillary light reflex in critical care patients | Advice | NICE